Aller-Essentials contains a blend of nutrients and herbal extracts designed to maintain healthy seasonal immune function. EpiCor® Saccharomyces cerevisiae fermentate contains numerous immune enhancing bioactive metabolites designed to support both innate and adaptive immune response. Research suggests that it enhances natural killer cell activation, B cell and T cell function, and salivary IgA levels. In a double-blind, placebo-controlled trial involving 96 subjects, EpiCor® supported nasal comfort during a 12-week period in the spring. Additionally, it supported salivary IgA levels, an important first line defense produced by the mucosal tissue. In a randomized double blind trial involving 75 individuals, Tinospora cordifoliaprovided significant support for a healthy immune response by maintaining normal nasal function as well as healthy neutrophil and eiosinophil activity. A randomized double blind, placebo-controlled trial involving apple polyphenols reveals support for maintaining a healthy nasal lining and nasal function. Quercetin, hesperidin and vitamin C provide additional support for stabilizing mast cells.